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実績

発表論文（2010年以降）

2017年

  1. Tanabe, K., Okazaki, R., Kaizuka, K., Inoue, Y. H.: Time-lapse Observation of Chromosomes, Cytoskeletons and Cell Organelles during Male Meiotic Divisions in Drosophila. Bio-protocol 7(8), 1-15, 2017 DOI:10.21769/BioProtoc.2225
  2. Nakamura A., Tanaka, R., Morishita, K., Yoshida, H., Higuchi, Y., Takashima, H. and Yamaguchi, M.: Neuron-specific knockdown of the Drosophila fat induces reduction of life span, deficient locomotive ability, shortening of motoneuron terminal branches and defects in axonal targeting. Genes Cells in press, 2017.
  3. Piccolo, L. L. and Yamaguchi M.: RNAi of arcRNA hsrω affects sub-cellular localization of DSrosophila FUS to drive neurodiseases. Exp. Neurol. 292, 125-134, 2017.
  4. Morishita, K., Suong, D. N. A., Yoshida, H. and Yamaguchi M.: The Drosophila DOCK family protein Sponge is required for development of the air sac primordium. Exp. Cell Res. 354 (2), 95-102, doi: 10.1016/j.yexcr.2017.03.044., 2017.
  5. Thuy An, P. N., Yamaguchi, M. and Fukusaki E.: Metabolic profiling of Drosophila melanogaster metamorphosis: A new insight into the central metabolic pathways. Metabolomics, 13:29, DOI 10.1007/s11306-017-1167-1, 2017.
  6. Otsuki, R., Yamamoto, M., Matsumoto, E., Iwamoto, S., Sezutsu, H., Suzui, M., Takaki, K., Wakabayashi, K., Mori, H., Kotani, E. Bioengineered silkworms with butterfly cytotoxin-modified silk glands produce sericin cocoons with a utility for a new biomaterial Proc. Natl. Acad. Sci. USA (in press)
  7. Abe, S., Tabe, H., Ijiri, H., Yamashita, K., Hirata, K., Atsumi, K., Shimoi, T., Akai, M., Mori, H., Kitagawa, S., Ueno, T. Crystal engineering of self-assembled porous protein materials in living cells. ACS Nano 11, 2410–2419 (2017)

2016年

  1. Hayashi, D., Tanabe, K., Katsube, H., and Inoue, Y. H.: B-type nuclear lamin and the nuclear pore complex Nup107-160 influence a formation of the spindle envelope required for cytokinesis in Drosophila male.”Biol Open 0. 1-11, 2016.
  2. Nguyen, T. B., Ida, H., Shimamura, M., Kitazawa, D., Akao, S., Yoshida, H., Inoue, Y. H., Yamaguchi, M. Role of SCOX in determination of Drosophila melanogaster lifespan. American J. Cancer Res.4(4): 325–336. 2014
  3. Goto, M., Toda, N., Shimaji, K., Suong, D. N. A., Vo, N., Kimura, H., Yoshida, H., Inoue, Y. H. and Yamaguchi, M.:Polycomb-dependent nucleolus localization of Jumonji/Jarid2 during Drosophila spermatogenesis. Spermatogenesis, 6:3, e1232023, DOI: 10.1080/21565562.2016.1232023. 2016
  4. Ali, Md. S., Mishra, B., Polan, M. S., Ninagi, O., Swapon, A. H. and Yamaguchi, M.: Regulation studies of a cuticle protein underlying genomic analysis. Int. J. Mol. Genet. Gene Ther. 1(2): doi http://dx.doi.org/10.16966/2471-4968.104, 2016.
  5. Nakajima, E., Shimaji, K., Umegawachi, T., Tomida, S., Yoshida, H., Yoshimoto, N., Izawa, S., Kimura, H., Yamaguchi, M.: The histone deacetylase gene Rpd3 is required for starvation stress resistance. PLoS One, 11 (12), e0167554, doi: 10.1371/journal.pone.0167554., 2016.
  6. Vo, N., Suong, D. N. A., Yoshino, N., Yoshida, H., Cotterill, S. and Yamaguchi, M.: Novel roles of HP1a and Mcm10 in DNA replication, genome maintenance and photoreceptor cell differentiation. Nucleic Acids Res. 45(3): 1233-1254, 2017 pii: gkw1174. [Epub ahead of print], PMID:27903903, 2016.
  7. Umegawachi, T.*, Yoshida, H.*, Koshida, H., Yamada, M., Ohkawa, Y., Sato, T., Suyama, M., Krause, H. M. and Yamaguchi, M.: Control of tissue size and development by a regulatory element in the yorkie 3’UTR. Am. J. Cancer Res. 7(3), 673-687, 2017.
  8. Shimaji, K., Konishi, T., Yoshida, H., Kimura, H. and Yamaguchi, M.: Genome-wide genetic screen identified the link between dG9a and epidermal growth factor receptor signaling pathway in vivo. Exp. Cell Res., 346(1): 53-64. doi: 10.1016/j.yexcr.2016.06.013., 2016.
  9. Nakazawa, M., Matsubara, H., Matsushita, Y., Watanabe, M., Vo, N., Yoshida, H., Yamaguchi, M. and Kataoka, T.: The human Bcl-2 family member Bcl-rambo localizes to mitochondria and induces apoptosis and morphological aberrations in Drosophila. PLoS One, 11(6): e0157823. doi: 10.1371/journal.pone.0157823, 2016.
  10. Thanh T. M., Tran B. D., Yamaguchi, M., Huy, T. N., and Kamei, K.: Function of lipid storage droplet 1 (Lsd1) in wing development of Drosophila melanogaster. Int. J. Mol. Sci. 17(5). pii: E648. doi: 10.3390/ijms17050648., 2016.
  11. Thanh T. M., Van D. N. T., Yamaguchi, M., Suzuki, T., Hattori, G., Arii, M., Huy, T. N., and Kamei, K.: A Drosophila model for screening anti-obesity agents. Biomed Res. Int., 2016:6293163. doi: 10.1155/2016/6293163., 2016.
  12. Kyotani, A., Azuma, Y., Yamamoto, I., Yoshida, H., Mizuta, I., Mizuno, T., Nakagawa, M., Tokuda, T., and Yamaguchi, M.: Knockdown of the Drosophila FIG4 induces deficient locomotive behavior, shortening of motor neuron, axonal targeting aberration, reduction of life span and defects in eye development. Exp. Neurol. 277, 86-95, doi: 10.1016/j.expneurol.2015.12.011. 2016.
  13. Tabe, H., Shimoi, T., Boudes, M., Abe, S., Coulibaly, F., Kitagawa, S., Mori, H., Ueno, T. Photoactivatable CO release from engineered protein crystals to modulate NF-ΚB activation. Chem. Commun. 52, 4545-4548 (2016)

2015年

  1. Oka, S., Hirai, J., Yasukawa, T., Nakahara, Y., and Inoue, Y. H. A correlation of reactive oxygen species accumulation by depletion of superoxide dismutases with age-dependent impairment in the nervous system and muscles of Drosophila adults. Biogerontol.16:485-501.DOI:10.1007/s10522-015-9570-3. 2015.
  2. Yasukawa, T., Nakahara, Y., Hirai J., and Inoue, Y. H. Drosophila Ogg1 is required to suppress 8-oxo-guanine accumulation following oxidative stress. Gene Genet Syst 90, 11-20. 2015.
  3. Huu, N. T., Yoshida, H. and Yamaguchi M.: Tumor suppressor gene OSCP1/NOR1 regulates apoptosis, proliferation, differentiation, and ROS generation during eye development of Drosophila melanogaster. FEBS J. 282(24), 4727-4746, doi: 10.1111/febs.13528. 2015.
  4. Shimaji K., Konishi, T., Tanaka, S., Yoshida, H., Kato, Y., Ohkawa, Y., Sato, T., Suyama, M., Kimura, H. and Yamaguchi, M.: Genome-wide identification of target genes of histone methyltransferase dG9a during Drosophila embryogenesis. Genes to Cells, 20 (11), 902-914, doi: 10.1111/gtc.12281. 2015.
  5. Huu, N. T., Yoshida, H. and Yamaguchi M.: Overexpression of tumor suppressor protein OSCP1/NOR1 induces ER stress and apoptosis during development of Drosophila melanogaster. American J. Cancer Res., 5(5), 1718-1729, PMID: 26175940. 2015.
  6. Abe, S., Ijiri, H., Negishi, H., Yamanaka, H., Sasaki, K., Hirata, K., Mori, H., Ueno, T. Design of enzyme-encapsulated protein containers by in vivo crystal engineering Adv. Mater. 27, 7951–7956. DOI: 10.1002/adma.201503827 (2015)
  7. Kotani, E., Yamamoto, N., Kobayashi, I., Uchino, K., Muto, S., Ijiri1, H., Shimabukuro, J., Tamura, T., Sezutsu, H., Mori, H. Cell proliferation by silk gut incorporating FGF-2 protein microcrystals. Sci. Rep. 5, 11051 DOI: 10.1038/srep11051 (2015)
  8. Matsumoto, G., Ueda, T., Sugita, Y., Kubo, K., Mizoguchi, M., Kotani, E., Oda, N., Kawamata, S., Segami, N., Mori, H. Polyhedral microcrystals encapsulating bone morphogenetic protein 2 improve healing in the alveolar ridge. J. Biomater. Appl. 30, 193-200 (2015)
  9. Tabe, H., Shimoi, T., Fujita, K., Abe, S., Ijiri, H., Tsujimoto, M., Kuchimaru, T., Kizaka-Kondo, S., Mori, H., Kitagawa, S., Ueno, T. Design of a CO-releasing extracellular scaffold using in-vivo protein crystals. Chem. Lett., 44, 342-344 (2015)
  10. Abe, S., Tokura, Y., Pal, R., Komura, N., Imamura, A., Matsumoto, K., Ijiri, H., Sanghamitra, N., Tabe, H., Ando, H., Kiso, M., Mori, H., Kitagawa, S., Ueno, T. Surface functionalization of protein crystals with carbohydrate using site-selective bioconjugation. Chem. Lett. 44, 29-31 (2015)

2014年

  1. Kitazawa, D., Matsuo, T., Kaiduka, K., Miyauchi, C., Hayashi, D., and Inoue, Y. H. Orbit/CLASP is required for myosin accumulation at the cleavage furrow in Drosophila male meiosis. PLoS One. 2014 9(5):e93669.
  2. Ali, Md. S., Swapon, A. H. and Yamaguchi, M.: Expression patterns of hypothetical cuticular protein genes in Bombyx mori. Eur. J. Biotech. Biosci. 2, 7-12, 2014.
  3. Vo, N., Horii, T., Yanai, H., Yoshida, H. and Yamaguchi, M.: The Hippo pathway as a target of the Drosophila DRE/DREF transcriptional regulatory pathway. Sci. Rep. 4, 7196, doi: 10.1038/srep07196. 2014.
  4. Morishita, K., Ozasa, F., Eguchi, K., Yoshioka, Y., Yoshida, H., Hiai, H. and Yamaguchi, M.: Drosophila DOCK family protein Sponge regulates the JNK pathway during thorax development. Cell Struct. Funct. 39, 113-124, 2014.
  5. Huu, N. T., Yoshida, H., Umegawachi, T., Miyata, S. and Yamaguchi, M.: Structural characterization and subcellular localization of Drosophila organic solute carrier partner 1. BMC Biochemistry, doi: 10.1186/1471-2091-15-11, 2014.
  6. Nguyen, T. B., Ida, H., Shimamura, M., Kitazawa, D., Akao, S., Yoshida, H., Inoue, Y. H. and Yamaguchi, M.: Role of SCOX in determination of Drosophila melanogaster lifespan. American J. Cancer Res., 4 (4), 325-336, PMID: 25057436, eCollection, 2014.
  7. Shimamura, M., Kyotani, A., Azuma, Y., Yoshida, H., Nguyen, T. B., Mizuta, I., Yoshida, T., Mizuno, T., Nakagawa, M., Tokuda, T. and Yamaguchi, M.: Genetic link between Cabeza, a Drosophila homologue of Fused in Sarcoma (FUS), and the EGFR signaling pathway. Exp. Cell. Res., 326, 36-45, doi:10.1016/j.yexcr.2014.06.004., 2014.
  8. Thuy An, P. N., Yamaguchi, M., Bamba, T. and Fukusaki, E.: Metabolome analysis of Drosophila melanogaster during embryogenesis. PLoS One, 9(8): e99519. Doi: 10.1371/journal.pone.0099519. 2014.
  9. Sahashi, R., Crevel G., Pasko, J., Suyari, O., Nagai, R., Saura, M. M., Yamaguchi, M. and Cotterill, S.: DNA polymerase alpha interacts with PrSet7 and mediates H4K20 monomethylation in Drosophila. J. Cell Sci. 127, 3066-3078, doi: 10.1242/jcs.144501. Epub 2014 May 7, 2014.
  10. Yanai, H., Yoshioka, Y., Yoshida, H., Nakao, Y., Plessis, A. and Yamaguchi, M.: Drosophila myeloid leukemia factor acts with DREF to activate the JNK signaling pathway. Oncogenesis 3:e98. doi: 10.1038/oncsis.2014.13. PMID: 24752236 [PubMed], 2014.
  11. Azuma, Y., Tokuda, T., Shimamura M., Kyotani, A., Sasayama H., Yoshida, T., Mizuta, I., Mizuno, T., Nakagawa, M., Fujikake, N., Ueyama, M., Nagai, Y. and Yamaguchi, M.: Identification of ter94, Drosophila VCP, as a strong modulator of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS. Hum. Mol. Genet. 23 (13), 3467-3480 (doi: 10.1093/hmg/ddu055.), 2014.
  12. Vo, N., Taga, A., Inaba, Y., Hideki, Y., Cotterill, S. and Yamaguchi, M.: Drosophila MCM10 is required for DNA replication and differentiation in the compound eye. PLoS ONE, 2014 Mar 31; 9(3):e93450. doi: 10.1371/journal.pone.0093450. eCollection 2014. PMID: 24686397, 2014
  13. Shimabukuro, J., Yamaoka, A., Murata, K., Kotani, E., Hirano, T., Nakajima, Y., Matsumoto, G., Mori, H. 3D co-cultures of keratinocytes and melanocytes and cytoprotective effects on keratinocytes against reactive oxygen species by insect virus-derived protein microcrystals. Mat. Sci. and Eng. C 42, 64-69 (2014)
  14. Matsumoto, G., Hirohata, R., Hayashi, K., Sugimoto, Y., Kotani, E., Shimabukuro, J., Hirano, T., Nakajima, Y., Kawamata, S., Mori, H. Control of angiogenesis by VEGF and endostatin-encapsulated protein microcrystals and inhibition of tumor angiogenesis. Biomaterials 35, 1326-1333 (2014)

2013年

  1. Yasuno, Y., Inoue, Y. H. and M. Yamamoto: Elimination of Y chromosome-bearing spermatids during spermiogenesis in an autosomal sex-ratio mutant of Drosophila simulans. Genes. Genet. Syst. 88, 113-126, 2013
  2. Yasuno, Y., Inoue, Y. H. and M. Yamamoto: Distribution and morphological changes of the Golgi apparatus during Drosophila spermatogenesis. Dev Growth Differ. 55:635-47, 2013
  3. Miyauchi, C., Kitazawa, D., Ando, I. and Inoue, Y. H: Orbit/CLASP is required for germline cyst formation through its developmental control of fusomes and ring canals in Drosophila males. : An essential gene for male germline cyst formation. PLoS One 8(3): e58220 2013
  4. Sahashi, R., Matsuda, R., Suyari, O., Kawai, M., Yoshida, H., Cotterill, S. and Yamaguchi, M.: Functional analysis of Drosophila DNA polymerase p58 subunit. Am. J. Cancer Res. 3(5), 478-489, 2013.
  5. Ida, H., Suyari, O., Shimamura, M., Tran, T. T., Yamaguchi, M. and Taketani, S.: Genetic link between Heme Oxygenase and the signaling pathway of DNA damage in Drosophila melanogaster. Tohoku J. Exp. Med. 231, 117-125, 2013.
  6. Kawamori, A., Shimaji, K. and Yamaguchi, M.: Control of e2f1 and PCNA by Drosophila transcription factor DREF. Genesis, 51, 741-750, 2013.
  7. Kawamori, A., Shimaji, K. and Yamaguchi, M.: Temporal and spatial pattern of dref expression during Drosophila bristle development. Cell Struct. Funct., 38, 169-181, 2013.
  8. Eguchi, K., Yoshioka, Y., Yoshida, H., Morishita, K., Miyata, S., Hiai, H. and Yamaguchi, M.: The Drosophila DOCK family protein Sponge is involved in differentiation of R7 photoreceptor cells. Exp. Cell Res., 315 (14), 2179-2195, 2013.
  9. Sugimoto, T., Ueda, T., Yoshida, H., Murakami, A. and Yamaguchi, M.: Overexpression of Drosophila RFX3 induces apoptosis and interferes with differentiation of photoreceptor cells. J. Carcinogene. Mutagene., 4, issue 1, 2013. DOI: http://dx.doi.org/10.4172/2157-2518.1000137
  10. Ly, L.L., Suyari, O., Yoshioka, Y., Tue, N.T., Yoshida, H. and Yamaguchi, M.: dNF-YB plays dual roles in cell death and cell differentiation during Drosophila eye development. Gene, 520 (2), 106-118, 2013.

2012年

  1. Ushijima Y., Inoue, Y. H, Konishi, T., Kitazawa, D., Yoshida, H., Shimaji, K., Kimura, H. and Yamaguchi, M..: Roles of histone H3K9 methyltransferases during Drosophila spermatogenesis. Chromosome Res. 20 (3), 319-331, 2012.
  2. Kitazawa, D., Yamaguchi, M., Mori, H., Inoue, Y. H. COPI-mediated membrane trafficking is required for cytokinesis in Drosophila male meiotic divisions. J. Cell Sci. 125, 3649-3660 (2012)
  3. Matsumoto, G., Ueda, T., Shimoyama, J., Ijiri, H., Omi, Y., Yube, H., Sugita, Y., Kubo, K., Maeda, H., Kinoshita, Y., Arias, D. G., Shimabukuro, J., Kotani, E., Kawamata, S., and Mori, H. Bone regeneration by polyhedral microcrystals from silkworm virus. Sci. Rep. 2, 935 DOI: 10.1038/srep00935 (2012)
  4. Shimizu, T., Ishikawa, T., Iwai, S., Ueki, A., Sugihara, E., Onishi, N., Kuninaka, S., Miyamoto, T., Toyama, Y., Ijiri, H., Mori, H., Matsuzaki, Y., Yaguchi, T., Nishio, H., Kawakami, Y., Ikeda, Y., Saya, H. Fibroblast growth factor-2 (Fgf2) is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma. Mol. Cancer Res. 10, 454-468 (2012)
  5. Shimizu, T., Ishikawa, T., Iwai, S., Ueki, A., Sugihara, E., Onishi, N., Kuninaka, S., Miyamoto, T., Toyama, Y., Ijiri, H., Mori, H., Matsuzaki, Y., Yaguchi, T., Nishio, H., Kawakami, Y., Ikeda, Y., Saya, H. Fibroblast growth factor-2 (Fgf2) is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma. Mol. Cancer Res. 10, 454-468 (2012)
  6. Matsumoto, G., Ueda, T., Shimoyama, J., Ijiri, H., Omi, Y., Yube, H., Sugita, Y., Kubo, K., Maeda, H., Kinoshita, Y., Arias, D. G., Shimabukuro, J., Kotani, E., Kawamata, S., and Mori, H.: Bone regeneration by polyhedral microcrystals from silkworm virus. Sci. Rep. 2, 935 DOI: 10.1038/srep00935 (2012)
  7. Shimizu, T., Ishikawa, T., Iwai, S., Ueki, A., Sugihara, E., Onishi, N., Kuninaka, S., Miyamoto, T., Toyama, Y., Ijiri, H., Mori, H., Matsuzaki, Y., Yaguchi, T., Nishio, H., Kawakami, Y., Ikeda, Y., Saya, H.: Fibroblast growth factor-2 (Fgf2) is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma. Mol. Cancer Res. 10 454-468 (2012)
  8. Yoshioka, Y., Ly, L. L. and Yamaguchi, M. : Transcription factor NF-Y is involved in differentiation of R7 photoreceptor cell in Drosophila. Biology Open 1, 19-29, 2012 (doi:10.1242/bio.2011013).
  9. Fujiwara, S., Ida, H., Yoshioka, Y., Yoshida, H. and Yamaguchi, M. : The warts gene as a novel target of the Drosophila DRE/DREF transcription pathway. Am J. Cancer Res. 2 (1) 36-44, 2012.
  10. Valadez-Graham, V., Yoshioka, Y., Velazquez, O., Kawamori, A. Vazquez, M., Neumann, A., Yamaguchi, M. and Zurita, M.: XNP/dATRX interacts with DREF in the chromatin to regulate gene expression. Nucleic Acids Res. 40(4), 1460-1474, 2012.
  11. Tue, N. T., Shimaji, K., Tanaka, N. and Yamaguchi, M. : Effect of áB-crystallin on protein aggregation in Drosophila. J. Biomed. Biotech. Volume 2012, Article ID 252049, 7 pages, doi:10.1155/2012/252049, 2012
  12. Suyari, O., Kawai, M., Ida, H., Yoshida, H., Sakaguchi, K. and Yamaguchi, M. : Differential requirement for the N-terminal catalytic domain of the DNA polymerase ε p255 subunit in the mitotic cell cycle and the endocycle. Gene 495 (2), 104-114, 2012
  13. Yoshioka, Y., Tue, N. T., Fujiwara, S., Matsuda, R., Valadez-Gtaham, V., Zurita, M. and Yamaguchi, M. : Drosophila DREF acting via the JNK pathway is required for thorax development. Genesis in press (doi: 10.1002/dvg.22017).
  14. Herz, H.-M., Mohan, M., Garrett, A.-S., Miller, C., Casto, D., Zhang, Y., Seidel, C., Haug, J. S., Florens, L., Washburn, M. P., Yamaguchi, M., Shiekhattar, R. and Shilatifard, A.: Polycomb repressive complex 2-dependent and –independent functions of Jarid2 in transcriptional regulation in Drosophila. Mol. Cell. Biol. 32 (9), 1683-1693, 2012.
  15. Bras, S., Martin-Lanneree, S., Gobert, V., Auge, B., Breig, O., Sanial, M., Yamaguchi, M., Haenlin, M., Plessis, A. and Waltzer, L.: MLF is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis. Proc. Natl. Acad. Sci. USA 109 (13), 4986-4991, 2012.
  16. Thao, D. T. P, Thuy An, P. N., Yamaguchi, M., Thuoc, T. L.: Overexpression of ubiquitin carboxyl terminal hydrolase impairs multiple pathways during eye development in Drosophila melanogaster. Cell Tissue Res. 348, 453-463, 2012.
  17. Kawamori, A., Shimaji, K. and Yamaguchi, M. : Dynamics of endoreplication during Drosophila posterior scutellar macrochaete development. PLoS ONE 7(6), e38714, 2012.
  18. Sasayama, H., Shimamura, M., Tokuda, T., Azuma, Y., Yoshida, T., Mizuno, T., Nakagawa, M., Fujikake, N., Nagai, Y. and Yamaguchi, M. : Knockdown of the Drosophila Fused in Sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches. PLoS ONE 7(6), e39483, 2012.
  19. Hashimoto, R., Yoshida, H. and Yamaguchi, M. : Sarcoglycan complex formation is involved in regulation of EGFR signaling during Drosophila eye development. HOAJ Biology, 1(1) DOI:　http://dx.doi.org/10.7243/2050-0874-1-7, 2012
  20. Ueda T., Kobori, A., Yamayoshi, A., Yoshida, H., Yamaguchi, M. and Murakami, A.: RNA-based diagnosis in a multicellular specimen by whole mount in situ hybridization using an RNA-specific probe. Bioorganic & Medicinal Chemistry 20, 6034-6039, 2012
  21. Kitazawa, D., Yamaguchi, M., Mori, H. and Inoue, Y. H.: COPI-mediated membrane trafficking is required for cytokinesis in Drosophila male meiotic divisions. J. Cell Science, 125, 3649-3660.
  22. Ushijima Y., Inoue, Y. H., Konishi, T., Kitazawa, D., Yoshida, H., Shimaji, K., Kimura, H. and Yamaguchi, M.: Roles of histone H3K9 methyltransferases during Drosophila spermatogenesis. Chromosome Res. 20, 319-331, 2012.
  23. Park, J.-S., Choi, Y.-J., Thao, D. T. P., Kim, Y.-S., Yamaguchi, M. and Yoo, M.-A.: DREF is involved in the steroidogenesis via regulation of shadow gene. Am J. Cancer Res. in press.
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2011年

  1. Nishishita, N., Ijiri, H., Takenaka, C., Kobayashi, K., Goto, K., Kotani, E., Itoh, T., Mori, H., Kawamata, S.: The use of leukemia inhibitory factor immobilized on virus-derived polyhedra to support the proliferation of mouse embryonic and induced pluripotent stem cells. Biomaterials 32 3555-3563 (2011)
  2. Lee, S.-H., Kim, I-J., Kim, J.-G., Kim, Y.-S., Yamaguchi, M. and Yoo, M.-A.: Regulation of intestinal stem cell proliferation by human methyl-CpG-binding protein-2 in Drosophila. Cell Struct. Funct. 36 (2) 197-208, 2011.
  3. Tue, N. T., Yoshioka, Y. and Yamaguchi, M.: NF-Y transcriptionally regulates the Drosophila p53 gene. Gene 473, 1-7, 2011.
  4. Tu Anh, N. T., Nishitani, M., Harada, S., Yamaguchi, M. and Kamei, K.: A Drosophila model for the screening of bioavailable NADPH oxidase inhibitors and antioxidants. Mol. Cell. Biochem. 352, 91-98, 2011.
  5. Inoue, Y. H., Miyauchi, C., Ogata, T., Kitazawa D.Dynamics of cellular components in meiotic and premeiotic divisions in Drosophila males. InTech Meiosis 2011 66-86 (2011)
  6. Kato, Y., Ushijima, Y. and Yamaguchi, M.: Identification of nuclear localization signals of Drosophila G9a histone H3 methyltransferase. Cell Struct. Funct. 36, 121-129, 2011.
  7. Ichikawa, A., Kotaki, M., Sahashi, R., Yoshioka, Y., Yamaguchi, M. and Ikura, K.: Targeted overexpression of Drosophila transglutaminase-B induced characteristic phenotypes in a similar manner as transglutaminase-A. Biosci. Biotechnol. Biochem. 75, 1402-1404, 2011.
  8. Kawamori, A. and Yamaguchi, M.: DREF is critical for Drosophila bristle development by regulating endoreplication in shaft cells. Cell Struct. Funct. 36, 103-119, 2011.
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2010年

  1. Matsushima, K., Suyama, T., Takenaka, C., Nishishita, N., Ikeda, K., Ikada, Y., Sawa, Y., Jakt, L.-M., Mori, H., Kawamata, S. Secreted frizzled related protein 4 reduces fibrosis scar size and ameliorates cardiac function after ischemic injury. Tissue Engineering Part A, 16, 3329-3341. (2010)
  2. Ichikawa, A., Yamada, A., Sakamoto, H., Umehara, M., Yoshioka, Y., Yamaguchi, M. and Ikura, K.: Overexpression of transglutaminase in the Drosophila wing disc induced an extra wing crossvein phenotype. Biosci. Biotechnol. Biochem. 74, 2494-2496, 2010.
  3. Nagai, R., Hashimoto, R. and Yamaguchi, M.: Drosophila Syntrophins are involved in locomotion and regulation of synaptic morphology. Exp. Cell Res. 316, 2313-2321, 2010.
  4. Umehara, M., Ichikawa, A., Sakamoto, H., Yamada, A., Yoshioka, Y., Yamaguchi, M. and Ikura, K.: Over-expression of transglutaminase in the Drosophila eye imaginal disc induces a rough eye phenotype. Mol. Cell. Biochem. 342, 223-232, 2010.
  5. Park, J.-S., Kim, Y.-S., Kim, J.-G., Lee, S.-H., Park, S.-Y., Yamaguchi, M. and Yoo, M.-A.: Regulation of the Drosophila p38b gene by the transcription factor DREF in adult midgut. Biochim. Biophys. Acta. 1799, 510-519, 2010.
  6. Yamaguchi, M., Suyari, O., Nagai, R. and Takahashi, M.: dGirdin a new player of Akt /PKB signaling in Drosophila melanogaster. Front. Biosci. 15, 1164-1171, 2010. (Review)
  7. Kitajima, S., Kamei, K., Taketani, S., Yamaguchi, M., Kawai, F., Komatsu, A. and Inukai, Y.: Two chitinase-like proteins abundantly accumulated in latex of mulberry show insecticidal activity. BMC Biochem. 11, 6, 2010.
  8. Tue, N. T., Thao, D. T. P. and Yamaguchi, M.: Role of DREF in transcriptional regulation of the Drosophila p53 gene. Oncogene 29, 2060-2069, 2010.
  9. Nagai, R., Hashimoto, R., Tanaka, Y., Taguchi, O., Sato, M., Matsukage, A. and Yamaguchi, M.: Syntrophin-2 is required for eye development in Drosophila. Exp. Cell Res. 316, 272-285, 2010.
  10. Yamaguchi, M.: A novel neuronal differentiation mechanism in which Slug and Escargot are major players. Cell Cycle, 9, 2711, 2010. (Review)
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外部資金獲得

  • 日本学術振興会 頭脳循環を加速する戦略的国際研究ネットワーク推進プログラム「日英共同「PODS国際研究ネットワーク」による病理・生理・細胞生物学の新たな展開」
  • 新型インフルエンザ等新興・再興感染症研究事業「ポリオウイルス疑似粒子固定化多角体結晶の複合体形成評価法の開発と応用」平成25年度〜27年度
  • 基盤研究(B)「細胞内結晶化反応を利用した精密多層蛋白質材料の創成」平成27年度〜30年度
  • 基盤研究(C)一般「遺伝子組換えカイコによるプロテインモジュールの作製」平成27年度〜29年度
  • 基盤研究(B)「昆虫中腸幹細胞培養系を基盤とした生理学および病理学的実験プラットフォームの構築」平成29年度〜31年度
  • 日本学術振興会特別研究員奨励費「メンブレントラフィックによる細胞分裂の制御とそれに関わる遺伝子ネットワークの解明」平成23年度（分担者：井上喜博）
  • 基盤研究(C)一般「ショウジョウバエの細胞分裂に伴うオルガネラ動態とメンブレントラフィックによる制御」平成23年度〜25年度（代表者：井上喜博）
  • 基盤研究(C)一般「ショウジョウバエのミトコンドリア動態を監査する新規細胞周期チェックポイント機構」平成26年度〜28年度　（代表者：井上喜博）
  • 基盤研究(C)一般「ショウジョウバエの新規白血病モデルの癌化と自然免疫系による癌抑制のメカニズム解明」平成29年度〜31年度（分担者：井上喜博）
  • 基盤研究(C)一般「進行癌の予防と治療補完療法の研究：発症前診断法及び癌抑制機構再活性化の検討」平成28年度〜30年度　（分担者：山口政光）
  • 基盤研究(C)一般「植物の乳管細胞の防御機能に関する比較マルチオミクスと昆虫フェノミクス」平成28年度〜30年度　（分担者：山口政光）
  • 基盤研究(C)一般「転写因子NF-Yが制御する脂質代謝機構の解析と新規肝機能モデルの開発」平成27年度〜29年度　（分担者：山口政光）
  • 外国人特別研究員奨励費Cabezaの核内区画局在へのクロマチンリモデリング因子の機能とALS発症機構　平成27年12月〜29年11月　（分担者：山口政光）
  • 基盤研究(C)一般「飢餓ストレスに応答して作動する新規エピジェネティック制御システム」平成28年度〜30年度（代表者：山口政光）
  • Bill & Melinda Gates Foundation Grand Challenges Explorations: Oral vaccination by poliovirus-like particle protein chips (H23～H24)
  • JST研究成果展開事業A-step研究成果最適展開支援プログラム：経口摂取によって個体レベルで老化を抑制する食品の開発（分担者：井上喜博）
  • 基盤研究(C)「乳管細胞の新規な 抗病原体・害虫タ ンパク質遺伝子の 網羅的単離と機能 解析」平成23年〜25年（分担者：山口政光）
  • 基盤研究(C)「ショウジョウバエ ヒストンメチル化 酵素dG9a標的遺伝子のゲノムワイド探索 」平成24年〜26年（代表者：山口政光）
  • 基盤研究(C)「ショウジョウバエの精子形成過程における細胞の増殖と成長を制御する機構に関する研究 」平成23年〜25年（代表者：井上喜博）
  • 基盤研究(C)「疾患モデルショウジョウバエとカイコ多角体病ウイルス機能を活用した新創薬プロセス」平成21年〜23年（代表者：山口政光）
  • 特定領域研究「ショウジョウバエを用いた精子形成で働くエピゲノム制御因子の同定とネットワーク解明」平成21年〜22年（代表者：山口政光）
  • 特定領域研究「ショウジョウバエを用いた精子形成に必要なエピゲノム制御因子同定とネットワーク解明」平成23年〜24年（代表者：山口政光）
  • 基盤研究(A)「昆虫システムを活用したヒト疾患の発症機構の解析と新たな治療薬スクリーニング」平成22年~24年
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大学間連携プロジェクト

  • 京都３大学連携研究支援費「昆虫ならびに哺乳動物モデルを用いた新規アンチエイジング物質の同定と食の安全を確保するバイオ高感度検出システムの開発」（研究代表者：井上喜博）
  • 京都ヘルスサイエンス総合研究センター事業（発症治癒機構解明研究グループ）（研究分担者：井上喜博）
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産学共同研究実績　企業名（課題）

  • 大日本住友製薬株式会社
    （筋萎縮性側索硬化症（ALS）の新規ショウジョウバエモデルの作製とそれによる化合物評価、及び自閉症スペクトラム障害（ASD）原因候補遺伝子のショウジョウバエによる機能評価）
  • 環境衛生薬品株式会社
    （癌・代謝関連疾患モデルショウジョウバエの開発及び疾患モデルショウジョウバエの創薬応用研究）
  • ライオン株式会社
    （ショウジョウバエを用いたアンチエイジング活性物質のスクリーニング）
  • サントリーグローバルイノベーションセンター株式会社
    (ショウジョウバエ生体アッセイ系を用いた抗肥満素材の評価系の確立)
  • サントリーウエルネス株式会社
    (ショウジョウバエ生体アッセイ系を用いた機能性素材の寿命延長作用の研究)
  • 株式会社サン・クロレラ
    (クロレラ熱抽出物によるショウジョウバエの寿命延長効果測定試験研究)
  • 創造工房株式会社
    (農産物加工品に含まれるアンチエイジング活性物質の探索と同定)
  • Miz株式会社
    (水素分子によるショウジョウバエ寿命延長効果の検討)
  • 国際衛生株式会社
    (ミトコンドリアＤＮＡのＣＯ１領域のシーケンスによる昆虫種の同定)
  • 国立研究開発法人　医薬基盤・健康・栄養研究所
    (薬用植物エキスライブラリーを用いたヒト疾患モデル昆虫による創薬システムの開発研究)

※ショウジョウバエを用いれば、マウスやラットなどでは従来不可能とされた大規模な薬剤スクリーニングが可能です。疾患モデルショウジョウバエを用いて特定の疾患に効く薬剤を探索するだけでなく、天然物などに生体に直接効く有効成分が含まれていないかの調査もおこなっています。詳しい問い合わせは、info@kit-ibrc.comへお送りください。

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